Jeff Smith

SmithJC@missouri.edu

Research Interests
Dr. Charles J. Smith is an Assistant Professor in the Department of Radiology and The Radiopharmaceutical Sciences Institute, Research Assistant Professor at the Missouri University Research Reactor, and Adjunct Assistant Professor in the Nuclear Science and Engineering Institute and Department of Medical Pharmacology and Physiology at the University of Missouri-Columbia. He has been funded by the NIH and recently has been awarded a VA Merit Award (2005-2008) for a project titled “Preparation of Low-Valent Tc(I)/Re(I) Imaging/Therapeutic Agents. Dr. Smith has published in journals such as Cancer Research, Anticancer Research, Bioconjugate Chemistry, Nuclear Medicine and Biology, and the Journal of Nuclear Medicine. Dr. Smith has graduate training in inorganic/organometallic/main group chemistry, with expertise in the design and development of polydentate, aqueous-soluble, phosphane containing ligands for Tc and Re radiometals. He has significant experience in radiopharmaceutical development including isotope processing and purification, tracer level and macroscopic metallation of small ligand frameworks and various biomolecular cell-targeting vectors, and in vitro and in vivo diagnostic/therapeutic radiopharmaceutical applications. Recently, Dr. Smith has focused his research efforts into the design and development of radiolabeled analogs of bombesin (BBN) with various radionuclides including ^99mTc, ¹⁸⁸Re, ¹¹¹In, ⁹⁰Y, ¹⁴⁹Pm, ¹⁷⁷Lu, and ¹⁵³Sm. Detailed investigations into the structure/activity of these new biomolecular tumor cell-targeting constructs in vitro and in vivo hold impetus for diagnosis and treatment of specific human cancers.

Professional Background

• B.S. in Chemistry: May of 1992, Missouri State University
• Ph.D. in Chemistry: May of 1997, University of Missouri-Columbia
• Assistant Professor, Department of Radiology, University of Missouri-Columbia School of Medicine and the Radiopharmaceutical Sciences Institute
• Research Scientist 8/8 Appointment, United States Department of Veterans Affairs, Harry S. Truman Memorial Veterans Hospital
• Research Assistant Professor, Missouri University Research Reactor
• Research Funding Through the United States Department of Veterans Affairs and the National Institute of Health.
• Member of the American Chemical Society
• Member of the Society of Nuclear Medicine
• International Consultant to the International Atomic Energy Agency
• Member of the International Society of Radiopharmaceutical Chemistry and Biology
• Editorial Board: Journal of Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Compounds
  

Selected Publications

• Smith, C.J.; Volkert, W.A.; and Hoffman, T.J. “Radiolabeled Peptide Conjugates for Targeting of the Bombesin Receptor Superfamily Subtype.” Nucl. Med. Biol., 2005, 32(7), 733-740.
• Giblin, M.F.; Veerendra, B.; and Smith, C.J. “Radiometallation of Receptor-Specific Peptides for Diagnosis and Treatment of Human Cancer.” In Vivo. New Anticancer Agents: In Vitro and In Vivo Evaluation, 2005, 19, 9-30.
• Faintuch B.L.; Santos R.L.S.R.; Souza A.L.F.M.; Hoffman T.J.; Greeley M.; and Smith C.J. “99mTc-HYNIC-Bombesin (7-14)NH2: Radiochemical Evaluation With Co-ligands EDDA (EDDA = Ethylenediamine-N,N’-diacetic Acid), Tricine, and Nicotinic Acid.” Journal of Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-metal Compounds, 2005, 35, 43-51.
• Smith, C.J.; Volkert, W.A.; and Hoffman, T.J. “Gastrin Releasing Peptide (GRP) Receptor-Targeted Radiopharmaceuticals: A Concise Update.” Nucl. Med. Biol., 2003, 30, 861-868.
• Smith, C.J.; Sieckman, G.L.; Owen, N.K.; Hayes, D.L.; Mazuru, D.L.; Volkert, W.A.; and Hoffman, T.J. “Radiochemical Investigations of [188Re(H2O)(CO)3-Dpr-SSS-Bombesin(7-14)NH2]: Syntheses, Radiolabeling, and In Vitro/In Vivo Studies Where Dpr = Diaminopropionic Acid.” Anticancer Research, 2003, 23(2), 63-70.
• Smith, C.J.; Sieckman, G.L.; Owen, N.K.; Hayes, D.L.; Mazuru, D.G.; Kannan, R.; Volkert, W.A.; and Hoffman, T.J. “Radiochemical Investigations of GRP Receptor-specific [99mTc(X)(CO)3- Dpr-Ser-Ser-Ser-Gln-Trp-Ala-Val-Gly-His-Leu-Met-(NH2)] in PC-3, Tumor-bearing, Rodent Models: Syntheses, Radiolabeling, and In Vitro/In Vivo Studies Where Dpr = 2,3-Diaminopropionic acid and X = H2O or P(CH2OH)3.” Cancer Research, 2003, 63, 4082-4088.
  

Methodology/Techniques
High Performance Liquid Chromatography of Small Molecules, Small Animal Positron Emission Tomography, Small Animal Magnetic Resonance Imaging, Small Animal Single Photon Emisson Computed Tomography, In Vivo Fluorescent Imaging Assays via Xenogen IVIS, In Vitro Internalization and Externalization Assays, In Vivo Pharmacokinetic and Biodistribution Assays of Radiopharmaceuticals.