Keith H. Byington , PhD.
Research interests
In recent years my research has consisted of tests of the hypothesis that
phosphate esters of the catecholamines have physiologic roles and
examination of these esters as prodrugs. A phosphate ester of dopamine
has been synthesized and used to show that the ester occurs in the brain
and heart. Current research is designed to detect the physiologic roles of
the phosphate esters of dopamine.
My students and I have investigated the effects of some drugs and toxic substances in vitro and in vivo. Currently my research is focused on tests of the hypothesis that the phosphate esters of the catecholamines have physiological and pharmacological roles.
Selected Publications
- B. S. in chemistry from the University of Iowa
- Ph.D. in pharmacology from the University of South Dakota
- Postdoctoral research at the University of Florida
- Postdoctoral research at the University of Wisconsin
- Joined the Department in 1968
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Member of several scientific societies
Selected Publications
- M.S. Department of Cell Biology, Jagiellonian University (Krakow, Poland)
Byington, K.H. and Leibman, K.C. Metabolism of trichloroethylene in liver microsomes. Mol. Pharmacol. 1: 247-254, 1965.
- Byington, K.H., Smoley, J. M. and Green, D. E. On the fragmentation of mitochondria by diethylstilbesterol. Arch. Biochem. Biophys. 127: 756-765, 1968
- Hill, R. D., Ford, S., Byington, K. H. Tzalogoff, A. and Boyer, P. D. Properties of a polar 32P-phospholipid isolated from particulate mitochondrial ATPase. Arch. Biochem. Biophys. 127: 756-765, 1968.
- Yeh, J. Z. and Byington, K. H. Interactions of acetaldehyde, ethyl alcohol and oxybarbiturates affecting mitochondrial functions. Biochem. Pharmacol. 22: 2045-2057, 1973.
- Byington, K. H., Yates, D.A. and Mullins, W.A. Binding of triethyllead chloride by hemoglobin. Toxicol. Appl. Pharmacol. 52:379-385, 1980.
- Henry, R. and Byington, K.H. Inhibition of glutathione-S-aryltransferase of rat liver by organogermanium, lead and tin compounds. Biochem. Pharmacol. 25:2291-2295, 1976.
- Byington, K. H. and Hansbrough, E. Inhibition of the enzymatic activity of ligandin by organogermanium, organolead or organotins compounds and the biliary excretion of sulfobromophthalein by the rat. J. Pharmacol. Exp. Ther. 208: 248-253, 1979.
- Byington, K.H. Evidence for the phosphorylation of dopamine by striatial tissue from the rat brain. Life Sci. 53:749-754, 1993.
- Byington, K.H. Detection of dopamine-tissue adducts. Life Sci. 63:41-44, 1998.
Methodology/Techniques
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