Kevin C. Dellsperger, M.D

Chairman, Professor of Medicine DellspergerK@health.missouri.edu Dept. of Medicine

Reserach Interests
Our laboratory evaluates mechanisms of vascular function in health and disease. Our studies currently evaluate both large conduit vascular function as well as microvascular function in collaboration with many groups throughout campus. We are focusing on the pulmonary circuit and evaluating various models of pulmonary hypertension and the influence of systemic hypertension on the pulmonary vasculature. We study how vessels respond to both constrictor and dilator stimuli and their underlying mechanisms for control. Techniques that are used in the laboratory include in vitro conduit and microvascular reactivity measurements, in vivo physiological measurements as well as biochemical and molecular measurements to elucidate signaling pathways in ex vivo tissue or isolated cells. Collaborators include Drs. Vince DeMarco, James Sowers, and M. Harold Laughlin.

Professional Background

• MD/PhD from Louisiana State University, Shreveport, LA
• Residency, Fellowship, Chief Residency Training – University of Iowa
• Faculty at the University of Iowa
• Recipient of an Individual NIH NRSA, NIH Clinical Investigator Award and an Established Investigator of the American Heart Association
• Past member of VA and NIH study sections
• Editorial Boards of American Journal of Physiology: Heart and Circulatory Physiology, Journal of Biomechanics
• Research funded over the years by American Heart Association, NIH, VA and American Diabetes Association.
  
  

• Oltman, C.L., Clark, C.B., Kane, N.L., Zhang, Y., Gutterman, D.D., Dellsperger, K.C. and Kerber, R.E.: Coronary Vascular Dysfunction Associated with Direct Current Shock Injury. Basic Res. Cardiol. 98:406-415, 2003.
• Oltman, C.L., Kane, N.L., Miller, F.J., Jr., Spector, A.A., Weintraub, N.L. and Dellsperger, K.C. Reactive Oxygen Species Mediate Arachidonic Acid-Induced Dilation in Porcine Coronary Microvessels. Am. J. Physiol: Heart Circ. Physiol. 285:H2309-15; 2003.
• Kaduce, T.L., Fang, X., Harmon, S.D., Oltman, C.L., Dellsperger, K.C., Teesch, L.M., Gopal, V.R., Falck, J.R., Campbell, W.B., Weintraub, N.L., and Spector, A.A.: 20-HETE Metabolism in Coronary Endothelial Cells. J. Biol. Chem. 279:2648-2656; 2004.
• Gavrila, D., Li, W.G., Daugherty, A., Cassis, L.A., Miller, F.J., Jr., Oberley, L.J., Dellsperger, K.C., Weintraub, N.L.: Vitamin E Inhibits Abdominal Aortic Aneurysm Formation in Angiotensin II – Infused, Apolipoprotein E Deficient Mice. Arterio. Thromb. Vasc. Biol. 25:1671-77, 2005.
  
  

Methodologies/Techniques