Jamal Ibdah, M.D., Ph.D.

Jamal Ibdah, M.D., Ph.D. Professor of Biochemistry Ibdahj@health.missouri.edu

Reserach Interests
Dr. Ibdah has many research interests some of which include molecular biology of fatty acid oxidation, adult and pediatric fatty liver disease, and liver disease in pregnancy, the role of nutrition in liver disease, and nonalcoholic steatohepatitis. His laboratory is focused on studying the molecular basis of diseases associated with fatty acid oxidation defects. The emerging clinical significance of these recessively inherited genetic disorders have stimulated to a great extent molecular research in this field. Pediatric deficiency is associated with a variety of clinical manifestations including liver, cardiac, and neuromuscular phenotypes. Ongoing studies in Dr. Ibdah’s laboratory are designed to elucidate the molecular basis and underlying pathogenesis of these different phenotypes using human subjects and animal models.

Dr. Ibdah’s primary clinical interests include hepatology, nonalcoholic fatty liver disease, and liver disease in pregnancy, as well as nutrition.

Professional Background

• Raymond E. and Vaona H. Peck Endowed Chair in Gastroenterology, University of Missouri at Columbia, 2005
• Professor of Internal Medicine/Gastroenterology, and Medical Pharmacology & Physiology, University of Missouri-Columbia
• Chief, Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Missouri-Columbia
• Senior Associate Dean for Clinical and Translational Research, University of Missouri-Columbia
• MD, University of Jordan
• PhD, Biochemistry, Medical College of Pennsylvania
• Residency, North Carolina Baptist Hospital (Wake Forest University)
• Fellowship, Washington University/Barnes-Jewish Hospital
• Graduate School Scholarship Award, 1984-1987
• North American Conference for Gastroenterology Fellows Award for an Outstanding Program Presentation, Tampa, Florida, March 1997
• Medical Foundation Teaching Scholar Award, Wake Forest University, 1997-1998
• Medical Foundation Teaching Scholar Award, Wake Forest University, 1998-1999
• Outstanding Investigator in Clinical Sciences Award, Wake Forest University, 2000
• "Who's Who in America", 58th edition of Marquis Who's Who, 2004
• Editorial Board, World Journal of Gastroenterology
• Member, Ad Hoc, Hepatobiliary Pathophysiology (HBPP) study section, NIH
  
  

Selected Publications

• Ibdah JA, Bennett MJ, Rinaldo P, et al. A fetal fatty acid oxidation disorder as a cause of liver disease in pregnant women. N Engl J Med 1999; 340: 1723-1731.
• Ibdah JA, Paul H, Zhao Y, et al. Lack of mitochondrial trifunctional protein in mice causes neonatal hypoglycemia and sudden death. J Clin Invest 2001; 107: 1403-1409.
• Yang Z, Yamada J, Zhao Y, Strauss AW, Ibdah JA. Prospective screening for mitochondrial trifunctional protein defects in pregnancies complicated by liver disease. JAMA 2002; 288; 2163-2166.
• Blish KR, Ibdah JA. Maternal heterozygosity for mitochondrial trifunctional protein defect as a cause for liver disease in pregnancy. Med Hypotheses 2005; 64: 96-100.
• Gilbert J, Ibdah JA. Intestinal pseudo-obstruction as a manifestation of impaired mitochondrial fatty acid oxidation. Med Hypotheses 2005; 64: 586-589.
• Ibdah JA, Perlegas P, Zhao Y, et al. Mice heterozygous for a defect in mitochondrial trifunctional protein develop hepatic steatosis and insulin resistance. Gastroenterology 2005; 128: 1381-1390
• Abdeen, M.B., Showdhury, N.A., Hayden, M.R. and Ibdah, J.A. “Nonalcoholic Steatohepatitis and the cardiometabolic syndrome”. JCMS 1:36-40, 2006.
• Mishra, G., Zhao, Y., Sweeney, J., Pineau, B., Case, D. Ho, C., Blackstock, W. Geisinger, K. Howerton, R., Levine, E., Shen, P., and Ibdah, J. “Assessment of telomerase activity in samples obtained from pancreatic lesions by endoscopic ultrasound guided fine needle aspiration (EUS-FNA) is clinically useful”. Gastrointest. Endosc 63:648-54, 2006.
  

Methodologies/Techniques