> Faculty > Joint Appointment Faculty > Edward H. Blaine

Edward H. Blaine , Ph.D.

Professor BlaineE@missouri.edu

Research Interests
My research interest centers on neuroendocrine regulation of fluid balance and cardiovascular
function with emphasis on hypertension and heart failure. In recent years various members of our research
team have studied the action of angiotensin in the central nervous system and the physiological as well as
pharmacological actions of the cardiac hormone, atrial natriuretic peptide. We have also been investigating renal excretory function and blood pressure regulation and will continue this important work. In addition, our interests are expanding into the extracellular matrix as a volume regulatory organ and the role of angiotensin and bradykinin in atherosclerotic plaque formation. My laboratory supports investigation at all levels from molecular to systems integration. As director of the Dalton Cardiovascular Research Center, I personally
encourage strong collaborative ties among scientists on the campus. Our research program interacts
significantly with investigators throughout the University community.

Professional Background

• Obtained Ph.D. in physiology from the University of Missouri
• Postdoctoral work at the Howard Florey Institute for Experimental Physiology
  and Medicine, University of Melbourne
• Awarded Honorary D.Sc. from the University of Missouri
• Joined Department in 1992
• Director, Dalton Cardiovascular Research Center
• Elected member of several professional societies including the American
  Physiological Society, American Society for Pharmacology and Experimental
  Therapeutics, The Endocrine Society, The Council for High Blood Pressure
  Research, and the American Society of Hypertension
• Member of the editorial boards of Hypertension and American Journal of
  Physiology, past senior editor, Monsanto Technical Journal
• NIH Career Development Awardee
• Served on numerous NIH and AHA review panels and site visit teams

Selected Publications

• Blaine, E.H. Atrial natriuretic factor plays a significant role in body fluid
  homeostasis. Hypertension 15:2-8, 1990.
• Smits, G.J., J.P. Koepke, and E.H. Blaine. Reversal of low-dose angiotensin
  hypertension by angiotensin receptor antagonists. Hypertension 18:17-21,
  1991.
• Olins, G.M., G.J. Smits, J.P. Koepke, H.-C. Huang, D.B. Reitz, R.E. Manning and
  E.H. Blaine. In vivo pharmacology of SC51316, a nonpeptide angiotensin II
  receptor antagonist. Am. J. Hypertens. 6:619-625, 1993.
• Schuh, J.R., D.J. Blehm, G.E. Frierdich, E.G. McMahon, and E.W. Blaine.
  Differential effects of renin-angiotensin system blockade in cholesterol-fed
  rabbits. J. Clin. Invest. 91:1453-1458, 1993.
• Li, Q., W.E. Dale, E.M. Hasser, and E.H. Blaine. Acute and chronic angiotensin
  hypertension: Neural and non-neural components, time course and dose-
  dependency. Am. J. Physiol. 271:R100- R207, 1996.
• Li, Q., M.J. Sullivan, W.E. Dale, S.M. Hasser, E.H. Blaine, and J. T.
  Cunningham. Fos-like immunosensitivity in the medulla following acute and
  chronic angiotension and infusion. J. Pharmacol. Expr. Ther., 1997 (in press).

Methodology/Techniques