Allan W. Jones , Ph.D.
Research Interests
My research program currently focuses on
mechanisms of membrane regulation and vascular
smooth muscle function leading to abnormalities
associated with hyper- lipidemia as well as
adaptative echanisms during exercise training.
We are studying mechanisms of adenosine
transport and adenosine regulation of smooth
muscle responses to acute metabolic depression
in porcine coronary arteries. These studies have shown a novel mechanism by which smooth muscle generated adenosine has an autocoid
function during an ischemic response. Mechanisms being pursued relate to adenosine
interaction with receptors and subsequent cellular events causing relaxation; as well as
adenosine interaction with a target enzyme, AMP kinase, which in turn regulates both cell
metabolism and functional responses. We have observed that exercise training may alter the
sensitivity of vascular smooth muscle in the porcine coronary arteries especially in males.
Gender studies have also been initiated. These studies involve close collaboration with
members of a program project team on exercise physiology, the Center for Gender
Physiology and Environmental Adaptation, and the Center for Diabetes and Cardiovascular
Health. Methods utilize microfluorometry of calcium probes, digital image analyses, patch
clamp techniques, radio isotopes fluxes, contractile responses, phosphor-image analyses,
and biochemical and immuno-measures of AMP kinase.
Professional Background
- Received Ph.D., Department of Physiology, University of Pennsylvania, 1965
- Postdoctoral study, Department of Pharmacology, Oxford University
- Joined Department in 1972
- Named James O. Davis Professor in Cardiovascular Research
- Chair of the Department of Physiology in 1983-2002
- Interim Chair, Department of Medical Pharmacology and Physiology 2002-
- Interim Director, Center for Diabetes and Cardiovascular Health, 2002
- Associate Director of the Dalton Cardiovascular Research Center
- Elected member of societies including: The American Physiological Society,
- American Society for Pharmacology and Experimental Therapeutics, and
Council for High Blood Pressure Research
- Past chair of the Experimental Cardiovascular Sciences Study Section of the
National Institutes of Health (NIH)
- Research program has been continuously funded for 28 years
- A National MERIT awardee of the NIH
Selected Publications
- Jones AW, Magliola L, Waters CB, Rubin LJ. Endothelin-1 activates phospholipases
and channels at similar concentrations in porcine coronary arteries. Am J Physiol 1998; 274:C1583-C1591.
Magliola L, Jones AW . Calcium-tension relationship in mesenteric arteries from
normotensive and aldosterone hypertensive rats. J Vasc Res 1999; 36:404-414.
- Jones AW, Rubin L, Magliola L. Endothlin-1 sensitivity of procine coronary arteries is
reduced by exercise training and is gender dependent. J Appl Physiol 1999;87:1172-1177.
- Rubin LJ, Johnson LR, D'halla AK, Magliola L, Laughlin MH, Jones AW. Selective
transport of adenosine into porcine coronary smooth muscle. Am J Physiol 2000; 279:H1397-H1410.
- Dhalla AK, Dodam J, Jones AW, Rubin, LJ. Characterization of an NBTI-sensitive
equilibrative nucleoside transporter in vascular smooth muscle. J Mol Cell Cardiol 2001; 33:1143-1154.
- Laughlin MH, Schrage W, McAllister R, Garverick HA, Jones AW . Interaction of
gender and exercise training: vasomotor reactivity of porcine skeletal muscle arteries. J Appl Physiol 2001; 90:216-227.
Methodology/Techniques
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