> Faculty > Professors > Albert Y. Sun

Albert Y. Sun , Ph.D.

Professor SunA@missouri.edu

Research interests
A.Y. Sun’s research interest is primarily on the study of membrane biochemistry in the central nervous system. Investigations include studying (Na+K)-ATPase, kainic acid neurotoxicity, membrane lipid peroxidation, free radical mechanisms in alcoholic brain damage and aging, oxidative stress in neurodegenerative disorders. He has used fluorescent probes to study the fluidity changes in biological membranes and membrane lipid peroxidation. He has been using cell culture system (PC-12 cells and primary neuronal cells) to study the mechanisms in apoptotic cell death under oxidative stress. Recently he has established the animal stroke model to study the delay neuronal cell death after ischemia/reperfusion insults, in order to understanding the cell death mechanisms and their protection by polyphenol antioxidants.

Professional Background
Department of Medical Pharmacology and Physiology
University of Missouri
Columbia, MO 65212
Phone: 573-882-1565
Fax: 573-884-4558

Ph.D. in Biochemistry, Department of Biochemistry, Oregon State University,
Corvallis, Oregon, 1967.
Postdoctoral Research Fellow in Department of Biochemistry, Case-Western
Reserve University, Cleveland, Ohio, 1967-1968.

1967-1968: Postdoctoral Res. Assoc. Biochem. Dept, Case Western Reserve U., Cleveland, OH. (Mentor: Dr.             Harland Wood)
1968-1974: Res. Scientist, Lab. of Neurochem., Cleveland, Psychiatric Inst., OH
1972-1974: Proj. Dir., Lab. of Neurochem., OH Mental Health & Mental Retard., Res. Ctr., Cleveland, OH
1974-1990: Res. Prof. of Biochem., Sinclair Comp. Med. Res. Ctr., Univ. Missouri, Columbia, MO
1977-1989: Associate Professor, Biochemistry Dept., Univ of Missouri, Columbia, MO
1989-1991: Associate Professor, Dept. of Pharmacology, Univ. Of Missouri, Columbia, MO
1991-2003: Professor, Dept. of Pharmacology, Univ. of Missouri, Columbia MO
2003-Present: Professor, Department of Medical Pharmacology and Physiology,Univ. Missouri, Columbia MO

SOCIETY MEMBERSHIP: Amer. Assoc. for the Adv. of Sci.; Research Soc. for Alcoholism; Amer. Soc. for Neurochem.; Amer. Soc. for Neurosci.; Int’l. Soc. for Neurochem.; Int’l Soc. Biomed. Res. Alcoholism; Amer. Soc. Biochem. & Molec. Biol.

HONORS: Recipient of NIH RO1 Grant (1980-1998) on Alcohol-membrane interaction in the brain. Chair of Workshop on Ethanol and Oxidative Stress in ISBRA International Meeting in Yokohama, Japan, July, 2000 and Co-organizer 0f the International Symposium on Recent Advances in the Biomedical Research in Alcoholism in Taipei, July, 2000. Co-organizer of a Satellite Symposium of the international Society for Neurochemistry on Neurodegenerative disorders in Guiling, China, February, 2004. Invited speaker on French paradox at the International Conference of the International Society for Biomedical Research in Alcoholism, Mannheim, Germany, September 2004.

Recent Publications

• Sun, A.Y., Ingelman-Sundberg, M., Neve, E., Matsumoto, H., Nishitani, Y., Minowa, Y., Fukui, Y., Bailey, S.M., Patel,V.B., Cunningham, C.C., Zima, T., Fialova, L., Mikulikova, L., Popov, P., Malbohan, I., Janebova, M., Nespor, K., and Sun, G.Y. (2001) Ethanol and oxidative stress. Alcoholism: Clin. & Exp. Res. 25:237S-243S.
• Sun, A.Y., Simonyi, A. and Sun, G.Y., (2002) The French Paradox and Beyond: Neurodegenerative Effects of Polyphenols. Free radical Biology & Medicine 32:314-318.
• Simonyi A., Woods D., Sun A.Y., and Sun G.Y. (2002) Grape polyphenols inhibit chronic ethanol-induced COX-2 mRNA expression on rat brain. Alcoholism: Clin & Expt. Res. 26:352-257
• Wang Q., Xu J.F., Rottenghaus G.E., Simonyi A., Lubahn D., Sun G.Y. and Sun A.Y. (2002) Resveratrol protects against global cerebral ischemic injury in gerbils. Brain Res. 958:439-447
• Xu J., Yu S., Sun A.Y., and Sun G.Y. (2003)Oxidant-mediated AA release from astrocytes involves cPLA2 . Free Radical Biology & Medicine 34:1531-1543.
• Xu J., Chalimonius M., Shu Y., Simonyi A., Sun A.Y., Gonzalez F.A., Weissman G.A., Wood W.G. and Sun G.Y. (2003) Prostaglandin E2 production in astrocytes: regulation by cytokines, extracellular ATP, and oxidative agents. Prostaglandins, Leukotrienes and Essential Fatty Acids. 69: 437-448
• Wang Q., Yu S., Simonyi A., Rottenghaus G., Sun G.Y., and Sun A.Y. (2004) Resveratrol reduces neurotoxicity induced by kainic acid. Neurochem. Res. (in press)

Methodology/Techniques